APPROACHES FOR CHEMICAL SYNTHESIS AND DIVERSE PHARMACOLOGICAL SIGNIFICANCE OF PYRAZOLONE DERIVATIVES: A REVIEW

Pyrazolone is a five-membered lactam ring containing two Nitrogens and one ketonic group in its structure. Numerous pyrazolone derivatives were exhibited with diverse biological, pharmacological, chemical applications. When pyrazolones discovered, they only known as NSAIDs but recent times play versatile role several complications like cerebral ischemia, cardiovascular diseases, antibacterial, antioxidant, anticancer other pharmacological activities. Over the last few decades, have been used for various biochemical Some of these such metamizole, phenazone, aminopyrine, propyphenazone, are widely anti-inflammatory analgesics. The chemistry has gained increasing attention due to properties anticancer, analgesic, anti-inflammatory, antimicrobial, antifungal, antiviral, antidiabetic, biological Thus, keeping because their importance, synthetic strategies existing well novel developed explored utility. This review deals different puts schemes.